A new homepage!
Finally, some php/mysqli support...
A new bachelor student!
Tatjana Kuen will join our team. Good luck with your work!
Science Slam Innsbruck 2022!
Alexander Weiss presented our work at the national Science Slam in Innsbruck 2022. Well done!
A new exciting article!
Heilmann, E., Costacurta, F., Moghadasi, S. A., Ye, C., Pavan, M., Bassani, D., et al.
SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376,
Science Translational Medicine (2022), DOI:10.1126/scitranslmed.abq7360
A new exciting article!
Holzknecht, M., Guerrero-Navarro, L., Petit, M., Albertini, E., Damisch, E., Simonini, A., et al.
The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT?20 cells in vitro,
FEBS Letters (2022), DOI:10.1002/1873-3468.14462
A new exciting article!
Andric, A, Wagner E., Heberle A., Holzknecht M., Weiss A. K. H.,
Extraction and Purification of FAHD1 Protein from Swine Kidney and Mouse Liver,
J. Vis. Exp. (180), e63333, DOI:10.3791/63333
New team members!
Anne Heberle, Andreas Andric, and Lisa Kleon will join our team!
Good luck with your work!
A new master student!
Tiziano Paravicini will join our team!
Good luck with your work!
A new exciting article!
Weiss, A. K. H., Wurzer, R., Klapec, P., Eder, M. P., Loeffler, J. R., von Grafenstein, S., et al.,
Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1),
Molecules 26, 5009 (2021), DOI:10.3390/molecules26165009
A new exciting article!
Gerna, D., Arc, E., Holzknecht, M., Roach, T., Jansen-Dürr, P., Weiss, A. K. H., et al.,
AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis?,
Int. J. Mol. Sci. 22, 2997 (2021), DOI:10.3390/ijms22062997
New team members!
Our team will grow =)
In the next month, we will welcome Franziska Nobis, Jakob Gamper, Tiziano Paravicini, Maria Milosevic and Anne Heberle!
Good luck with your work!
A new bachelor student!
Matthias Rainer Scheppach joined the team in November 2020. He will help in the production of FAHD1 overexpression vectors to be used in cell culture experiments.
Welcome and good luck!
Preis der Landeshauptstadt Innsbruck 2020!
Alexander Weiss was awarded with the Prize of the state capital Innsbruck for scientific research 2020.
Congratulations!
Lange Nacht der Forschung 2020!
We contributed to the Long night of research 2020. Find the video at "Was macht man eigentlich in der Biomedizinsichen Alternsforschung?".
Enjoy!
Interviewed by Makademia.at!
Makademia.at asked us for an interview. Find the text at "Das ewige Leben... oder auch nicht".
Thank you for your interest in our work!
A new bachelor student!
Eva Wagner joined the team in September 2020. She will extract FAHD1 protein from swine kidney using a set of proteomic approaches including fast protein liquid chromatography (FPLC). Using purified FAHD1 protein she will study the effect of selected molecules and ions on the catalytic activity of the enzyme.
Welcome and good luck!
A new master student!
Anna Simonini joined the team in February 2020 when she worked on a project study to investigate the untranslated 5' region upstream of the human FAHD1 promoter region on chromosome 16. She studied transcription factors in this region and performed pilot studies on how this bi-directional promoter region may be regulated under normoxic and hypoxic conditions in U2OS cells. She will continue these experiments in the course of her masters thesis starting August 2020 and also study the overexpression of human FAHD1 on the background of endogeneous FAHD1 depleted cancer cells.
Welcome and good luck!
A new bachelor student!
Andreas Andric joined the team in Juli 2020. He will establish a protocol to extract FAHD1 protein from swine kidney using a set of proteomic approaches including fast protein liquid chromatography (FPLC). Using purified FAHD1 protein he will perform pilot experiments to study the catalytic activity of the enzyme, compared to recombinant enzyme obtained via expression in competent bacteria.
Welcome and good luck!
A highlight in 2019!
Our video supported article Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins was recently published by the Journal of Visualized Experiments (JoVE) with more than 5500 clicks in the first year! We will incorporate it as educational material in our lectures and are eager to continue this work in the future.
Great work by all people involved, and a big Thank You for all your support!
Science Slam Innsbruck 2019!
Alexander Weiss presented his work at the national Science Slam in Innsbruck 2019. Well done!